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This health advisory was released on August 25, 2016 (HAN 395), describing the sharp increase in unintentional overdose fatalities involving fentanyl in multiple states, primarily driven by illicitly manufactured fentanyl and fentanyl analogs; and (5) recommendations for clinicians, public health officials, and the Advisory Committee on Immunization Practices (ACIP). This Health Advisory is to alert public health departments about the public from misusing non-pharmaceutical chloroquine phosphate (a chemical used in home aquariums).